[Bone and joint injuries among young patients in Gorgan, Iran [2009]]

Musculoskeletal injuries are the common causes of disabilities among young patients. This study was done to establish the causes and clinical evidences of bone and joint injuries among young patients in Gorgan, Iran. This cross-sectional study was carried out on 600 subjects with musculoskeletal injuries reffered to 5 Azar teaching hospital in Gorgan, north of Iran during 2009. Age, sex, type of initial treatment, location of injury and medical treatment for subjects were completed. Data were analyzed using SPSS-16, Chi-Square and student t-tests. The mean age of subjects was 25 +/- 7 years. 83% of subjects were male. In 37% of injured people, time of accident was between 12 to 18 o'clock. The most common causes were car accident [49.7%], workplace injury [15.3%], falling down [10.3%], respectively. Street [38.3%] and road [18.7%] were the location with high accident. Fractures [71.7%], soft tissue injuries [48.3%] and dislocation [8.7%] were the most common injuries. Upper and lower limb were the most common in injury and fractur, respectively. This study showed that young men are more prone to accident and occupation injuries

[Immunohistochemical evaluation of Ki-67 antigen, p27kipl and MCM3 proteins in odontogenic keratocysts]

Odontogenic keratocysts are usually in need of extensive treatment and are concerned mostly by researches in order to find their biological behavior. Minichromosome maintenances [MCM3] over-expression has been reported in several human beings affected by odontogenic. To our knowledge there is no article about MCM3 expression in odontogenic keratocyst. The aim of this study was to evaluate MCM3 in odontogenic keratocysts and compare it to Ki-67 and p27. Total of 23 OKC specimens were selected from Razi laboratory, they were reconfirmed by two indipendent pathologists. Clinicohistopathological data were recorded and standard streptavidin-biotin peroxidase method of immuohistochemical [IHC] staining was conducted for Ki-67 antigen, p27 Kipl and MCM3. The immunostained cells were counted on 10 HPF [Labeling Index] and then classified to negative, low, moderate and high levels. Statistical analysis was done by SPSS 13 using Freidman and Spearman's Rho tests and PLUM - Ordinal Regression. P-value less than 0.05 were considered significant. Ki-67 was stained mostly in the basal and suprabasal cells but p27 was found in the upper layers. No sample was stained by MCM3. There were significant differences among these proteins [MCM3 compared with Ki-67 and p27] not between p27 and Ki-67. No correlation was found among age, location and lesion size with these markers. Most of the odontogenic keratocysts expressed low levels of both Ki-67 and p27. We also found MCM3 is not implicated in the pathogenesis of OKC